Give Your Intellect a Boost — Just Say Yes to Doing the Right Drugs!
By Mathew Honan 04.21.08 | 6:00 PM

Get Smarter: 12 Hacks That Will Amp Up Your Brainpower
1: Distract Yourself
2: Caffeinate With Care
3: Choose Impressive Information
4: Think Positive
5: Do the Right Drugs
6: Juice Your IQ Score
7: Know Your Brain
8: Don't Panic
9: Embrace Chaos
10: Get Visual
11: Exercise Wisely
12: Slow Down

Plus: 6 Intelligence Myths Exposed

A Beautiful Mind: Steve Carell on How to Act Brilliant

The Memory Master: Want to Remember Everything You’ll Ever Learn? Surrender to This Algorithm.

Brains + drugs = fried eggs, right? Not always.

 Some pills can boost your cognitive output. But we at Wired aren't doctors. Anyone who takes a bushel of drugs based on our say-so must be high.



Drugs     What it does        Possible side effects
Adderall     Thought to optimize levels of dopamine and norepinephrine, enhancing concentration and turning mundane tasks into wondrous ones. Often prescribed to ADHD patients (wink, wink).    

    Addiction, headaches, insomnia, Tourette's-like symptoms, heart attack
Aniracetam     Seems to boost release of glutamate, speeding neurotransmission and improving memory. Not a ton of evidence, though.    

    Anxiety, agitation, insomnia, dizziness, epigastric heaviness (feeling full)
Aricept     An Alzheimer's drug that may also enhance memory in healthy adults. Thought to reduce the breakdown of acetylcholine, a neurotransmitter that helps relay messages around the brain.    

    Nausea, diarrhea, fainting
Methamphetamine     Triggers the release of dopamine. Can increase concentration and creative output. Prolonged use can also make you stupid and crazy.    

    Parkinson's-like symptoms, addiction, stroke, psychosis, prison, death
Modafinil     A narcolepsy medication that improves focus, pattern recognition, and short-term memory. The exact mechanism of action is unclear. Good for card counters.    

    Chest pain, nausea, headache, life-threatening rash
Nicotine     Chemically similar to the neurotransmitter acetylcholine. Spurs faster interaction between nerve cells in the brain, aiding memory formation and attention.    

    Addiction, cancer, social isolation (depending on delivery mechanism)
Rolipram     Originally used as an antidepressant. May elevate levels of cyclic adenosine monophosphate to boost memory. Improves cognition (in rats).    

    Headache, nausea, intense vomiting
Vasopressin     Produced naturally in the hypothalamus1 gland and used in the formation of new memories. Shown to help users learn more effectively (especially men). Prescribed as a drug for diabetes insipidus.    

    Angina, nausea, wheezing, belching, coma
Illustration: Christoph Niemann
 
Correction:
1Vasopressin is produced in the hypothalamus, not the pituitary gland, as previously reported.

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